EDUCATION

• 1981, Ph.D., Physics Dept., University of California, San Diego.;
  Project: software development for crystallographic data processing.
• 1981-1984, Postdoctoral Research, UC Los Angeles and ITRI.
  Projects: structure of RuBisCO; crystallographic methods development; toxicology.

EMPLOYMENT

• 1984-1993,Genex Corporation, Enzon, Inc.,, and Molecular Simulations, Inc., Gaithersburg and Rockville, MD.
  Projects: crystallographic methods development; structure determination.
• 1995-     Associate Professor, Biology Division, BCPS Dept., Illinois Institute of Technology, (tenured 2000)
  Projects: crystallographic methods development; structural genomics; pharmaceutical crystallography.
  Associate Director, Director, and Chief Scientific Officer, Industrial Macromolecular Crystallography Association CAT,    Advanced Photon Source, Argonne National Laboratory

RESEARCH SUPPORT

• PI or Co-PI on four SBIR projects and an NIH P01 project
• PI and Co-PI on IMCA-CAT project (see above); total managed funding over $25M.

  SCIENTIFIC COMMUNITY SERVICE

  • 1991-    NIH, NSF, NASA peer-review panels.
  • 1997-1999 Founder and first Chair, CAT Director's Council, APS
  • 2000     Chair, Diffraction Methods in Molecular Biology Gordon Conference

  SELECTED PUBLICATIONS (out of 41)

  • Howard, A.J. Nielsen, C.P., Xuong, Ng.-h (1984) Software for a multiwire area detector. Methods in Enzymology 114: 452-472.
  • Howard, A.J. et al (1986) Binding of nitropyrenes and benzo[a]pyrene to mouse lung deoxyribonucleic acid after pretreatment with inducing agents. Biochem.Pharmacol. 35: 2129-2134.
  • Howard, A.J. et al (1987) Use of an imaging proportional counter in macromolecular crystallography. J. Appl. Crystallogr. 20: 383:387.
  of cytochrome P-450cam. Biochemistry 26: 8165-8174.
  • Howard, A.J. and Poulos, T.L., (1992) Methods in macromolecular crystallography. chapter in Advances in Biophysical Chemistry 2: 1-36.
  • Howard, A.J. (2000) Data processing in macromolecular crystallography. Chapter in: Crystallographic Computing 7: Proceedings from the Macromolecular Crystallographic Computing School, 1996. P.E. Bourne and K.D. Watenpaugh, eds. Oxford: Oxford University Press.
  • Howard, A. (1998) Participation of pharmaceutical companies in synchrotron radiation research. Nature Structural Biology 5: 623-626.
  • Howard, A. (1999) Macromolecular crystallography at third-generation synchrotron sources. Chapter for Third Generation Hard X-ray Synchrotron Radiation Sources: Source Properties, Optics, and Experimental Techniques, Dennis Mills, ed. Wiley: 2002.
  • Eisenstein, E., et al (2000) Biological function made crystal clear - annotation of hypothetical proteins via structural genomics. Current Opinions in Biotechnology 11: 25-30.
  • Ladner, J.E., Reddy, P., Davis, A., Tordova, M., Howard, A.J., and Gilliland, G.L. (2000) The 1.30 Å resolution structure of the Bacillus subtilis chorimate mutase catalytic homotrimer. Acta Crystallographica D 56: 673-683.
  • Lim, K., et al (2001) Crystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-Adenosylhomocysteine. Proteins 45: 397-407.