Andrew J. Howard

Biological, Chemical, and Physical Sciences Department howard@iit.edu
Illinois Institute of Technology http://csrri.iit.edu/~howard/
3100 South Dearborn St., Chicago IL 60616 USA 312-567-5881, fax 312-567-3576

i. PROFESSIONAL PREPARATION
Pomona College, Claremont CA Biophysics B.A. 1975
University of California, San Diego Physics Ph.D. 1981
University of California, Los Angeles Mol.Biol. Postdoctoral 1983
Inhalation Toxicology Research Institute Toxicology Postdoctoral 1984

ii. APPOINTMENTS
Director, Masters in Health Physics Program BCPS Department, IIT 2002-present
Associate Professor, Biology & Physics BCPS Department, IIT 1998-present
Consulting crystallographer SER-CAT, Advanced Photon Source 2003-present
Chief Scientific Officer IMCA-CAT, Advanced Photon Source 2002-2004
Director IMCA-CAT, Advanced Photon Source 1996-2002
Research Associate Professor BCPS Department, IIT 1996-1997
Research Scientist Molecular Simulations, Inc. 1993-1995
Senior Research Scientist Enzon, Inc., Gaithersburg, MD 1991-1993
Corporate Research Scientist Genex Corporation, Gaithersburg, MD 1984-1991

iv. Selected Professional Activitites
Elected Member ACA Committee on Data Standards and Computing 2005-present (chair 2008):
Director ACA Summer School in Macromolecular Crystallography 2003-present
Member American Chemical Society 2003-present
Member American Crystallographic Association 1982-present
Chair Gordon Conference, Diffraction Methods in Molecular Biology 2000
Founder,first Chair CAT Director's Council, APS 1997-1999
Vice-Chair Gordon Conference, Diffraction Methods in Molecular Biology 1998

v. Research areas:
Macromolecular crystallographic methods development (1977-present), immune-system protein structure determination (1989-present), crystallographic applications of synchrotron radiation (1996-present), protein expression (1998-present), crystallographic education (2002-present)

vi. a. Seven Significant Publications (of approximately 80):

Howard, A. (2002) Macromolecular crystallography at third-generation synchrotron sources. Chapter for Third Generation Hard X-ray Synchrotron Radiation Sources: Source Properties, Optics, and Experimental Techniques. D.M. Mills, ed. Wiley: 406pp.

Howard, A.J. (2000) Data processing in macromolecular crystallography. Chapter in: Crystallographic Computing 7: Proceedings from the Macromolecular Crystallographic Computing School, 1996. P.E. Bourne and K.D. Watenpaugh, eds. Oxford: Oxford University Press.

Howard, A. (1998) Participation of pharmaceutical companies in synchrotron radiation research. Nature Structural Biology5: 623-626.

Howard, A.J. and Poulos, T.L., (1992) Methods in macromolecular crystallography. Chapter in Advances in Biophysical Chemistry2: 1-36.

Jin, T., Guo, F., Kim, S., Howard, A., and Zhang, Y.-Z. (2007) X-ray crystal structure of TNF ligand family member TL1A at 2.1 Å. Biochem.Biophys.Res.Comm. 364: 1-6.

Hoang, Q., Sicheri, F., Howard,A., Yang,D. (2003) Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature 425: 977-980.

Howard, A.J. Gilliland, G.L., Finzel, B.C. Poulos, T.L. Ohlendorf, D.H. and Salemme, F.R. (1987) Use of an imaging proportional counter in macromolecular crystallography. J. Applied Crystallogr.20: 383:387.

vii. Synergistic Activities:

Research Collaborators during the last 48 months:
O. Herzberg (U.Maryland Biotechnology Institute), J. Moult (U.Maryland Biotechnology Institute), B.C. Stark (IIT), Y.Zhang (IIT), J. Chrzas (U.Georgia/SER-CAT), H. Lum (Rush U.), H.Hofstetter (NIU)

viii. Undergraduate, Graduate and Postdoctoral Advising:

Over 100 academic advisees; nine undergraduate research students since 1998.
Current Ph.D. students: Shih-Chia Chang, Pauls Reinfelds, Sireesha Ratakonda, Gregory Sahli
Previous: K.-W. Park (Ph.D. 2002), K.-J. Kim (Ph.D. 1999, postdoc 1999-2002)., M. Vamvouka (postdoc (2006-2007)

ix: Teaching activities:
IIT courses:

  1. Introductory biochemistry (undergraduate and graduate): one-semester course, taught twice per year since 2001.
  2. Radiation biophysics (graduate): one-semester course, taught at least biennially since 1998.
  3. Macromolecular structure (graduate): one-semester course, team-taught in 2008.
  4. Introduction to the Professions (freshman survey): one-semester course, taught annually 1998-2006.
Other teaching and educational outreach:
  1. American Crystallographic Association Summer School in Macromolecular Crystallography (graduate and postdoc): 12-day intensive school for which I direct and do about one-third of the lectures; July, 2002-2008.
  2. Cold Spring Harbor Macromolecular Crystallography Course: annual 15-day graduate and postgraduate course, for which I contributed 2-3 lectures/year, 1997 to 2000.
  3. ACA Task force on Crystallography in Chemical Education, 2005
  4. Judge at Chicago area Junior Science and Humanities Symposium (high-school student science presentations), 2000-present.
  5. Judge and facilitator, Chicago Area Undergraduate Research Symposium, 2008.