Standard Free Energies of Hydrolysis of Metabolites

Values in kJ mol-1

Reactants Products ΔGo'  Reactant Products ΔGo'
PEP + HOH Pyruvate + Pi -62  3',5'-cyclic AMP + HOH 5'-AMP -50.4
1,3-BisP-glycerate + HOH 3-P-glycerate + Pi -49 ATP + HOH AMP + PPi -45 *
Acetyl phosphate + HOH Acetate + Pi -43 Phosphocreatine + HOH Creatine + Pi -43
ATP + HOH ADP + Pi -35.7* PPi + HOH Pi + Pi-33.6
Phosphoarginine + HOH Arginine + Pi -32   Acetyl CoA + HOH Acetate + CoASH -32
S-AdoMet + HOH met + ado -25.6   Glucose 1-P + HOH Glucose + Pi -21
Glucose 6-P + HOH Glucose + Pi -14   Fructose-1-P + HOH Fructose + Pi -16
Glycerol 3-P + HOH Glycerol + Pi -9   AMP-2 + HOH Ado + Pi -13

Pi is phosphate, typically H2PO4-
PPi is pyrophosphate, typically H2P2O7-2
PEP is phosphoenolpyruvate.
S-AdoMet is S-adenosylmethionine.

* Assuming low [Mg2+]. At high [Mg2+],
ΔGo' is -30.5 kJ/mol for ATP → ADP and roughly -41 kJ/mol for ATP → AMP.