Biology Department &
Center for Synchrotron Radiation Research & Instrumentation
LS 178 IIT, 3101 South Dearborn Street, Chicago, IL 60616
howard@iit.edu;
http://csrri.iit.edu/~howard/, 312-567-5881
i. PROFESSIONAL PREPARATION
| Pomona College, Claremont CA | Biophysics | B.A. | 1975 |
| University of California, San Diego | Physics | Ph.D. | 1981 |
| University of California, Los Angeles | Mol.Biol. | Postdoctoral | 1983 |
| Inhalation Toxicology Research Institute | Toxicology | Postdoctoral | 1984 |
ii. APPOINTMENTS
| Associate Professor, Biology & Physics | Biology Dept. & predecessors, IIT | 1998-present |
| Consulting crystallographer | SER-CAT, Advanced Photon Source | 2003-2014 |
| Co-Director, Masters in Health Physics Program | BCPS Department, IIT | 2002-2011 |
| Director / Chief Scientific Officer | IMCA-CAT, Advanced Photon Source | 1996-2004 |
| Research Associate Professor | BCPS Department, IIT | 1996-1997 |
| Research Scientist | Molecular Simulations, Inc. | 1993-1995 |
| Senior Research Scientist | Enzon, Inc., Gaithersburg, MD | 1991-1993 |
| Corporate Research Scientist | Genex Corp., Gaithersburg, MD | 1984-1991 |
iii. RESEARCH SUPPORT
v. Research areas:
Macromolecular crystallographic methods development (1977-present),
immune-system protein structure determination (1989-present),
crystallographic applications of synchrotron radiation (1996-present),
protein expression (1998-present),
crystallographic education (2002-present), secondary science education
(2014-present).
vi. a. Five Relevant Publications:
Ratakonda, S., Anand, A., Dikshit, K., Stark, B.C., and Howard, A.J. (2013) Crystallographic structure determination of B10 mutants of Vitreoscilla hemoglobin: role of Tyr29 (B10) in the structure of the ligand binding site. Acta Crystallogr. F69: 215-222.
Howard, A. (2002) Macromolecular crystallography at third-generation synchrotron sources. Chapter for Third Generation Hard X-ray Synchrotron Radiation Sources: Source Properties, Optics, and Experimental Techniques. D.M. Mills, ed. Wiley: 406pp.
Howard, A.J. (2000) Data processing in macromolecular crystallography. Chapter in: Crystallographic Computing 7: Proceedings from the Macromolecular Crystallographic Computing School, 1996. P.E. Bourne and K.D. Watenpaugh, eds. Oxford: Oxford University Press.
Eisenstein, E., Gilliland, G.L., Herzberg, O., Moult, J., Orban, J., Poljak, R.J., Banerjei, L., Richardson, D., and Howard, A.J. (2000) Biological function made crystal clear - annotation of hypothetical proteins via structural genomics. Current Opinions in Biotechnology 11: 25-30.
Howard, A. (1998) Participation of pharmaceutical companies in synchrotron radiation research. Nature Structural Biology5: 623-626.
vi. b. Five other publications
Guo, F., Kothary M.H., Wang Y., Yu X., Howard, A.J., and Zhang, Y.J. (2009) Purification and crystallization of Cor a 9, a major hazelnut allergen. Acta Crystallogr. F65: 42-46.
Jin, T., Chen, Y.-W., Howard, A., and Zhang, Y.-Z. (2008) Purification, crystallization and initial crystallographic characterization of the Ginkgo biloba 11S seed globulin ginnacin. Acta Crystallogr. F64: 641-644.
Albillos, S.M., Jin, T., Howard, A., Zhang, Y.-Z. Kothary, M.H., and Fu., T.J. (2008) Crystal Structure of Prunin-1, a Major Component of the Almond (Prunus dulcis) Allergen Amandin. J. Agric. & Food Chem., 56: 5352-5358.
Hoang, Q., Sicheri, F., Howard,A., Yang,D. (2003) Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature 425: 977-980.
Howard, A.J. Gilliland, G.L., Finzel, B.C. Poulos, T.L. Ohlendorf, D.H. and Salemme, F.R. (1987) Use of an imaging proportional counter in macromolecular crystallography. J. Applied Crystallogr.20: 383:387.
vii. Synergistic Activities and Selected Professional Activities:
Research Collaborators during the last 48 months:
B.C. Stark (IIT), Y.Zhang (IIT), J.Chrzas (U.Georgia / SER-CAT),
K. Dikshit (Chandigarh, India)
| Elected Member | ACA Continuing Education Committee | 2014-2017 |
| Elected Member | ACA Committee on Data Standards and Computing | 2005-2009 |
| Director | ACA Summer School in Macromolecular Crystallography | 2003-2008, subject to renewal |
| Member | American Crystallographic Association | 1982-present |
| Vice-Chair, Chair | Gordon Conference, Diffraction Methods in Molecular Biology | 1998, 2000 |
| Founder, Chair | CAT Director's Council, APS | 1997-1999 |
| Treasurer | IIT Sigma Xi Chapter | 2011-present |
viii. Undergraduate, Graduate and Postdoctoral Advising:
Over 20 academic advisees; 14 undergraduate research
students since 1998.
Previous: K.-W. Park (Ph.D. 2002, postdoc 2002-04),
S. Ratakonda (Ph.D. 2011), P. Reinfelds (Ph.D. 2012), Y. Wang (Ph.D. 2012),
K.-J. Kim (Ph.D. 1999, postdoc 1999-2002).
Current Master's students: D. Bai, Y. Pei.
Previous Master's students: Y. Zhang(2015),
S. Chang (2012), I. Muhamed (2010), others.